There are at least two studies using high viscosity
hydroxypropylmethylcellulose. The newer study (2007) was in overweight
and obese subjects whereas the 1993 article was in type 2 diabetics.
Dow Chemicals produces a product called FORTEFIBER which is a version of
high viscosity hydroxypropylmethylcellulose. I have not found a product
that includes FORTEFIBER as an ingredient.
1. RESULTS—Peak glucose was significantly lower (P < 0.001) after both
HV-HPMC–containing meals (7.4 mmol/l [4 g] and 7.4 mmol/l [8 g])
compared with the control meal (8.6 mmol/l). Peak insulin concentrations
and the incremental areas for glucose and insulin from 0 to 120 min were
also significantly reduced after both HV-HPMC doses versus control (all
P < 0.01).
CONCLUSIONS—These findings indicate that HV-HPMC consumption reduces
postprandial glucose and insulin excursions, which may favorably alter
risks for diabetes and cardiovascular disease.
High-Viscosity Hydroxypropylmethylcellulose Blunts Postprandial Glucose
and Insulin Responses -
http://care.diabetesjournals.org/cgi/content/full/30/5/1039
2. High viscosity hydroxypropylmethylcellulose reduces postprandial
blood glucose concentrations in NIDDM patients.
Reppas C, Adair CH, Barnett JL, Berardi RR, DuRoss D, Swidan SZ, Thill
PF, Tobey SW, Dressman JB.
Department of Pharmacy, University of Athens, Greece.
The ability of high viscosity hydroxypropylmethylcellulose (HPMC) to
reduce postprandial glucose concentrations was *****sed in patients with
non-insulin-dependent diabetes (NIDDM) and healthy volunteers. The study
design consisted of a two-way crossover, single-dose administration of
10 g prehydrated high viscosity HPMC, or placebo, with a standard
carbohydrate-rich meal. In patients with NIDDM, HPMC reduced blood
glucose concentrations at the 60-, 75-, 90-, 120- and 150-min sampling
intervals, with an average reduction in the maximum postprandial blood
glucose concentration, Cmax, of 24% (P < 0.05). The time at which the
maximum concentration was reached, Tmax, remained unchanged. The area
under the blood concentration versus time plot, AUC0-6h, was reduced by
an average of 15% (P < 0.05). The blood concentration profile of insulin
followed that of glucose. Concentrations were significantly lower than
in the placebo phase only at the 120-min sampling time, while
pharmacokinetic parameters (Cmax, Tmax and AUC0-6h) were unchanged.
These results suggest that alterations in the blood glucose profile are
mediated by luminal events rather than by changes in hormonal response.
In contrast to the NIDDM patients, neither the pharmacokinetic
parameters nor the blood glucose concentrations at specific sampling
times were significantly affected by the co-administration of HPMC in
healthy volunteers. Overall, the results of this study suggest that HPMC
may be a useful adjunct in the management of NIDDM.
PMID: 8137718 [PubMed
http://www.ncbi.nlm.nih.gov/pubmed/8137718
Don't take the following article as an indication that I don't sup****t a
low carbohydrate diet for type 2 diabetics.
"Additionally, from a nutritional standpoint, these diets
(Low-carbohydrate–high-protein diets) are seriously deficient in several
micronutrients and dietary fiber, thus creating a need for nutritional
supplements." Source: Low-carbohydrate–high-protein diets: Is there a
place for them in clinical cardiology? -
http://content.onlinejacc.org/cgi/content/full/43/5/725
Table 2 "Adverse" Consequences of LC-HP Diets -
http://content.onlinejacc.org/cgi/content/full/43/5/725/T2
Yet it does seem that some form of fiber supplementation can be useful
for health. FiberOne cereal is heavy in fiber but may have too much
carbohydtrate for many T2s. Guar gum and psyllium husks are available.
A few diabetics use defatted flax seed fiber as their fiber source.
Beta-glucans are also a useful fiber for delaying carbohydrate digestion.
"Supplementation of a high-carbohydrate breakfast with barley
beta-glucan improves postprandial glycaemic response for meals but not
beverages.
[...] There is evidence of postprandial blunting of blood glucose and
insulin responses to dietary carbohydrates when oat soluble fibre is
supplemented into the diet but few trials have been carried out using
natural barley or enriched barley beta-glucan products. The aim of this
trial was to investigate the postprandial effect of a highly enriched
barley beta -glucan product on blood glucose, insulin and lipids when
given with a high-CHO food and a high-CHO drink. [...] We conclude that
a high dose barley beta-glucan supplement can improve glucose control
when added to a high-CHO starchy food, probably due to increased
gastro-intestinal viscosity, but not when added to a high-CHO beverage
where rapid absorption combined with decreased beta-glucan concentration
and viscosity may obviate this mechanism." PMID: 17215176 [PubMed
Grain processing and nutrition. -
http://www.ncbi.nlm.nih.gov/pubmed/11307845
Frank
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