On Mon, 23 Jun 2008 07:06:17 +1000, Alan S
<loralgtweightandcarbs@[EMAIL PROTECTED]
> wrote:
>On Sun, 22 Jun 2008 21:24:44 +0200, Thorsten Schier
><usenet@[EMAIL PROTECTED]
> wrote:
>
>>Nick Cramer schrieb:
>>> gaguu wrote:
>>>
>>>>http://www.boingboing.net/2008/06/21/curry-vs-obesity-and.html
>>>>Findings presented to ENDO 2008, the Endocrine Society's annual
>>>>meeting in San Francisco this week, show that a spice found in curries
>>>>has remarkable properties when administered to obese and diabetic
>>>>mice:
>>>
>>>
>>> Did they say which curries and which spice?
>>>
>>
>>As others have already pointed out the active agent would be cur***in
>>from turmeric.
>>
>>Cur***in allegedly offers a whole host of health benefits:
>>
>>http://www.whfoods.com/genpage.php?tname=foodspice&dbid=78
>>
>>If you want to try it, I would advise to go directly for turmeric and
>>not for curry, because even with pure turmeric you would most likely
>>still need serveral grams per day to reap the full benefits.
>>
>>
>>Thorsten
>
>I'll need to do some searching, but I remember two points
>from much earlier discussions on turmeric on a.s.d., and
>cites provided.
>
>1. At rather low levels the dosage of turmeric was
>irrelevant, the main thing was to have some regularly.
>
>2. The effect of turmeric was amplified/complemented by
>adding piperine at the same time.
>
>I've been adding a pinch of turmeric and a grating of black
>pepper to my daily menu for several years since I first read
>that here.
>
>
>Cheers, Alan, T2, Australia.
A follow-up.
Here are the reasons why I add a little turmeric and cracked
pepper to my morning omelette or my lunch stir-fry, and I
often elect to eat Indian when I eat out.
The discussion on the effect on some cancers, including the
surprising comment that the amount didn't matter, was
actually on the www.acor.org web-site, which I used for my
CLL.
http://www.acor.org/news/whatsnew.html?item_id=3467
"HOUSTON - Cur***in, the pungent yellow spice found in both
turmeric and curry powders, blocks a key biological pathway
needed for development of melanoma and other cancers, say
researchers from The University of Texas M. D. Anderson
Cancer Center.
The study, to be published in the August 15, 2005 issue of
the journal Cancer, but available on line at 12:01 a.m.
(EDT) on Monday, July 11, demonstrates how cur***in stops
laboratory strains of melanoma from proliferating and pushes
the cancer cells to commit suicide."
<snip>
"Surprisingly, it didn't matter how much cur***in was used,
says the researchers. "The NF-kB machinery is suppressed by
both short exposures to high concentrations of cur***in as
well as by longer exposure to lower concentrations of
cur***in," they say in their study."
I haven't searched for the actual study referred to,
possibly someone else will post a link. A quick google
scholar search using the author Aggarwal, publication cancer
and search subjects turmeric and melanoma returned a lot of
papers: http://tinyurl.com/64vy4u
This was the other paper on turmeric and piperine, where it
is found that piperine increased effectiveness by 2000%.
Planta Med. 1998 May;64(4):353-6. Related Articles, Links
Influence of piperine on the pharmacokinetics of cur***in in
animals and human volunteers.
http://tinyurl.com/3hpl9y
or
http://www.uta.edu/faculty/sawasthi/Publications/References/2000%20Publications/Journal%2070/Do***ent%2070.36.pdf
Shoba G, Joy D, Joseph T, Majeed M, Rajendran R, Srinivas
PS.
Department of Pharmacology, St. John's Medical College,
Bangalore, India.
"The medicinal properties of cur***in obtained from Cur***a
longa L. cannot be utilised because of poor bioavailability
due to its rapid metabolism in the liver and intestinal
wall. In this study, the effect of combining piperine, a
known inhibitor of hepatic and intestinal glucuronidation,
was evaluated on the bioavailability of cur***in in rats and
healthy human volunteers.
When cur***in was given alone, in the dose 2 g/kg to rats,
moderate serum concentrations were achieved over a
period of 4 h. Concomitant administration of piperine 20
mg/kg increased the serum concentration of cur***in for a
short period of 1-2 h post drug. Time to maximum was
significantly increased (P < 0.02) while elimination half
life and clearance significantly decreased (P < 0.02), and
the bioavailability was increased by 154%.
On the other hand in humans after a dose of 2 g cur***in
alone, serum levels were either undetectable or very low.
Concomitant administration of piperine 20 mg produced much
higher concentrations from 0.25 to 1 h post drug (P < 0.01
at 0.25 and 0.5 h; P < 0.001 at 1 h), the increase in
bioavailability was 2000%. The study shows that in the
dosages used, piperine enhances the serum concentration,
extent of absorption and bioavailability of cur***in in both
rats and humans with no adverse effects."
Bon appetit.
Cheers, Alan, T2, Australia.
--
d&e, metformin 1500mg, ezetrol 10mg
Everything in Moderation - Except Laughter.
http://loraldiabetes.blogspot.com
http://www.flickr.com/photos/alan_s/
http://loraltravel.blogspot.com
(On Indian Roads)
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