On Apr 27, 10:49=A0am, "A M Jackson" <no.s...@[EMAIL PROTECTED]
> wrote:any
suggestions <<
"Unexplained joint complaints"
"We therefore advocate routine sampling of ferritin levels in
patients
with unexplained joint complaints"
Neth J Med. 2006 Sep;64(8):307-9. Links
S****adic ****phyria cutanea tarda due to haemochromatosis.
de Geus HR, Dees A.
Department of Intensive Care, Erasmus Medical Centre, Rotterdam, the
Netherlands.
Haemochromatosis is a hereditary iron-overload syndrome caused by
increased intestinal iron absorption and characterised by
ac***ulation of potentially toxic iron in the tissues.
Sometimes this disease presents as a cutanea ****phyria.
We describe a patient with joint complaints and blistering skin
lesions
on sun-exposed skin.
After identifying the ****phyria cutanea tarda by urine analysis we
found
that the serum activity of uro****phyrinogen decarboxylase (UROD) was
normal, meaning a partial inactivation of UROD in liver tissue due to
external factors.
Further investigation showed the homozygous Cys282Tyr
missense mutation and high levels of serum ferritin.
It is im****tant to recognise the symptoms of iron overloading at an
early stage because hereditary haemochromatosis needs to be treated
immediately.
We therefore advocate routine sampling of ferritin levels in patients
with
unexplained joint complaints.
PMID: 16990695
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> I am 62 years old. I am a right hand person.
>
> Around 9 months ago, my left middle finger=A1=AFs middle and bottom
joints=
> around the knuckle areas, started to be painful, particularly in the
> morning. When I tried to bend my middle finger, I feel the joint
movement
> not smooth, kind of snap and bounce like a toggle switch.
>
> I am unable to fold and curl my middle finger back to touch my palm,
like
> trying to hold a fist. When I put my finger in hot water, the joint
moveme=
nt
> is smoother and less painful. I am taking Glucosamine Hydrochloride
(1500m=
g)
> plug MSN (methylsulfonylmethane 1500mg) daily, but showing no help.
>
> My doctor has X-ray and blood test for Rheumatoid Arthritis. Everything
> tested normal.
>
> I have tried and see different physicians, physical therapist,
orthopedic
> specialists; none offer much explanation or help. Except one athletic
pers=
on
> suggested I have the =A1=B0soft bone=A1=B1 problem. This soft bone is
supp=
ose to be
> part of the ligament and cartilage tightening problem. But he did not
offe=
r
> much solution for my problem, except that I should have physical therapy
> exercise.
>
> After 8 months of daily left middle finger pains, now my left thumb
starts=
> having the same kind of pain too.
>
> Can anyone out there offer any suggestions and recommendations? Thank
you =
so
> much.
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